Current Scientific research on the benefits of Spirulina



  1. Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds.
  2. Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.
  3. Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.
  4. Radioprotectant and Cytotoxic Effects of Spirulina in Relapsed Verrucous Vulvar Cancer: A Case Report.
  5. Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae.
  6. Tumor necrosis factor in experimental cancer regression with alphatocopherol, beta-carotene, canthaxanthin and algae extract.
  7. Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice.
  8. Long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study).
  9. Prevalence and parental perceptions of complementary and alternative medicine use by children with cancerin a multi-ethnic Southeast Asian population.
  10. Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina platensis.
  11. Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina.
  12. The effect of ultrasonificated extracts of Spirulina maxima on the anticancer activity.
  13. Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins.
  14. Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors.
  15. Water soluble polysaccharides from Spirulina platensis: extraction and in vitro anti-cancer activity.
  16. Spirulina in health care management.
  17. Chemoprevention of rat mammary carcinogenesis by Spirulina.
  18. Targeting angiogenic pathway for chemoprevention of experimental colon cancer using C-phycocyanin as cyclooxygenase-2 inhibitor.
  19. Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines.
  20. The protective effect of dietary Arthrospira (Spirulina) maxima against mutagenicity induced by benzo[alpha]pyrene in mice.
  21. Isolation of methyl gamma linolenate from Spirulina platensis using flash chromatography and its apoptosis inducing effect.
  22.  Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth.
  23. In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enrichedSpirulina platensis.
  24. C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells.
  25. Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicinresistant human hepatocellular-carcinoma cell line HepG2.
  26. C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line.
  27. Enhancement of immune activation activities of Spirulina maxima grown in deep-sea water.
  28. Carvedilol and Spirulina may provide important health protection to smokers and other nicotine addicts: a call for pertinent research.
  29. Evaluation of chemoprevention of oral cancer with Spirulina fusiformis.
  30. Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-colored biliprotein of microalga Spirulina.
  31. [Effect of polysaccharide from Spirulina platensis on hematopoietic cells proliferation, apoptosis and Bcl-2 expression in mice bearing tumor treated with chemotherapy].
  32. Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/β-catenin signaling while up-regulating ligand dependent transcription factor PPARγ.
  33. Estimation of serum malondialdehyde in potentially malignant disorders and post-antioxidant treated patients: A biochemical study.
  34. Phycocyanin induces apoptosis and enhances the effect of topotecan on prostate cell line LNCaP.
  35. Regulatory effects of Spirulina complex polysaccharides on growth of murine RSV-M glioma cells through Toll-like receptor 4.
  36. Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles.
  37. Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin.
  38. Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.
  39. Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis.
  40. The use of complementary and alternative medicine among Malay breast cancer survivors.
  41. Cytotoxicity of algae extracts on normal and malignant cells.
  42. Modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice.
  43. The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA
  44. Spirulina platensis and related tetrapyrroles have potent antiproliferative effects on experimental human pancreatic cancer.

Cholesterol control

  1. A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
  3. Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: a preliminary report.
  4. The hepatoprotective and hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population with non-alcoholic fatty liver disease: a prospective pilot study.
  5. Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina.
  6. Effect of spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients.
  7. Effects of Spirulina platensis supplementation on lipid profile in HIV-infected antiretroviral naïve patients in Yaounde-Cameroon: a randomized trial study.
  8. Spirulina versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats.
  9. Effects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice.
  10. Hypolipidemic Effect of a Blue-Green Alga (Nostoc commune) Is Attributed to Its Nonlipid Fraction by Decreasing Intestinal Cholesterol Absorption in C57BL/6J Mice.
  11. Effects of fish oil and spirulina on oxidative stress and inflammation in hypercholesterolemic hamsters.
  12. Glucomannan and glucomannan plus spirulina added to pork significantly block dietary cholesterol effects on lipoproteinemia, arylesterase activity, and CYP7A1 expression in Zucker fa/fa rats.
  13. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients.

Diabetes and blood sugar regulation

  1. Antidiabetic Property of Spirulina.
  2. Ameliorative potential of aqueous cell extract of Spirulina platensis on diabetes associated metabolic alterations.  
  3. Role of Spirulina in the Control of Glycemia and Lipidemia in Type 2 Diabetes Mellitus.
  4. Effect of food diet supplements with chromium on the clinical and metabolic parameters in type 2 diabetic patients.
  5. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients.
  6. Effect of a zinc-enriched diet on the clinical and metabolic parameters in type 2 diabetic patients.
  7. Spirulina versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats.
  8. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients.
  9. A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
  10. Glucomannan and glucomannan plus spirulina-enriched squid-surimi added to high saturated diet affect glycemia, plasma and adipose leptin and adiponectin levels in growing fa/fa rats.
  11. Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes.
  12. Protective effects of polysacchride of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan induced diabetic rats.
  13. Exercise and spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar rats.
  14. Study on Hypoglycaemic Effect of Spirulina platensis on Long -Evans Rats.
  15. Attenuation  of  diabetic complications  by C-phycoerythrin in rats: antioxidant activity of C-phycoerythrin including copper-induced lipoprotein and serum oxidation.

"In light of the evidence, it makes sense for everybody to grow their own spirulina."

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