Current Scientific Research on the Benefits of Spirulina

divider
Contents

Detoxification

  • Preclinical antitoxic properties of Spirulina (Arthrospira).
  • Efficacy of Spirulina extract plus zinc in patients of chronic arsenic poisoning: A randomized placebo-controlled study.
  • The adaptive potentials of those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station under the influence of different treatment methods.
  • Arsenic-induced genotoxicity in Nile tilapia (Oreochromis niloticus); the role of Spirulina platensis extract.
  • Radioprotectant and cytotoxic effects of Spirulina in relapsed Verrucous Vulvar Cancer: A case report.
  •  Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test.
  •  The postradiation use of vitamin-containing complexes and a phycocyanin extract in a radiation lesion in rats.
  • The remedial efficacy of Spirulina platensis versus chromium-induced nephrotoxicity in male Sprague-Dawley rats.
  • Dietary strategies for the treatment of cadmium and lead toxicity.
  • Effect of Spirulina and Liv-52 on cadmium-induced toxicity in albino rats.
  • Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on a hemopoietic system of mice and dogs.
  • 5 Grams daily of Spirulina reversed severe radiation poisoning in Chernobyl children.

Anti-cancer

  • Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds.
  • Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.
  • Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.
  • Radioprotectant and cytotoxic effects of Spirulina in relapsed Verrucous Vulvar cancer: A case report.
  • Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae.
  • Tumour necrosis factor in experimental cancer regression with alpha-tocopherol, beta-carotene, canthaxanthin and algae extract.
  • Inhibition of tumour invasion and metastasis by calcium spirulin (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.
  • Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice.
  • The long-term effect of Spirulina platensis extract on DMBA-induced hamster buccal pouch carcinogenesis (immunohistochemical study).
  • Prevalence and parental perceptions of complementary and alternative medicine use by children with cancer in a multi-ethnic Southeast Asian population.
  • Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papilloma genesis by Spirulina platensis.
  • Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina.
  • The effect of ultrasonificated extracts of Spirulina maxima on the anti-cancer activity.
  • Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins.
  • Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors.
  • Water-soluble polysaccharides from Spirulina platensis: extraction and in vitro anticancer activity.
  • Spirulina in health care management.
  • Chemoprevention of rat mammary carcinogenesis by Spirulina.
  • Targeting the angiogenic pathway for chemoprevention of experimental colon cancer using C-phycocyanin as a cyclooxygenase-2 inhibitor.
  • Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines.
  • The protective effect of dietary Arthrospira (Spirulina) maxima against mutagenicity induced by benzo[alpha]pyrene in mice.
  • Isolation of methyl gamma linolenate from Spirulina platensis using flash chromatography and its apoptosis-inducing effect.
  • Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth.
  • In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis.
  • C-Phycocyanin inhibits cell proliferation and may induce apoptosis in human HepG2 cells.
  • Alteration of mitochondrial membrane potential by Spirulina platensis C-phycocyanin induces apoptosis in the doxorubicin-resistant human hepatocellular-carcinoma cell line HepG2.
  • C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in a human hepatocellular carcinoma cell line.
  • Enhancement of immune activation activities of Spirulina maxima grown in deep-sea water.
  • Carvedilol and Spirulina may provide important health protection to smokers and other nicotine addicts: a call for pertinent research.
  • Evaluation of chemoprevention of oral cancer with Spirulina fusiformis.
  • Digestion by pepsin releases biologically active chromopeptides from C-phycocyanin, a blue-coloured biliprotein of microalga Spirulina.
  • Effect of polysaccharide from Spirulina platensis on hematopoietic cells proliferation, apoptosis and Bcl-2 expression in mice bearing tumour treated with chemotherapy.
  • Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/β-catenin signalling while up-regulating ligand-dependent transcription factor PPARγ.
  • Estimation of serum malondialdehyde in potentially malignant disorders and post-antioxidant treated patients: A biochemical study.
  • Phycocyanin induces apoptosis and enhances the effect of topotecan on prostate cell line LNCaP.
  • Regulatory effects of Spirulina complex polysaccharides on the growth of murine RSV-M glioma cells through toll-like receptor 4.
  • Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anti-cancer efficacy of selenium nanoparticles.
  • Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin.
  • Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.
  • Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis.
  • The use of complementary and alternative medicine among Malay breast cancer survivors.
  • Cytotoxicity of algae extracts on normal and malignant cells.
  • The modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice.
  • The influence of Spirulina platensis filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA.
  • Spirulina platensis and related tetrapyrroles have potent antiproliferative effects on experimental human pancreatic cancer.

Anti-oxidant & Anti-inflammatory

  • The anti-inflammatory and antihyperalgesic activity of C-phycocyanin.
  • Hypolipidemic, antioxidant, and anti-inflammatory activities of microalgae Spirulina.
  • C-phycocyanin confers protection against oxalate-mediated oxidative stress and mitochondrial dysfunctions in MDCK cells.
  • Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages.
  • Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders.
  • C-phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects.
  • Purification and identification of antioxidant peptides from enzymatic hydrolysate of Spirulina platensis.
  • Role of pH on antioxidants production by Spirulina (Arthrospira) platensis.
  • Quantification of phytochemicals from commercial Spirulina products and their antioxidant activities.
  • Comparative evaluation of natural antioxidants Spirulina and aloe vera for the treatment of oral submucous fibrosis.
  • Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats.
  • Supercritical CO2 extraction of functional compounds from Spirulina and their biological activity.
  • Antioxidant effects and UVB protective activity of Spirulina (Arthrospira platensis) products fermented with lactic acid bacteria.

Endurance & Performance

  • Impact of dietary antioxidants on sports performance: A review.
  • Effect of Spirulina food supplement on blood morphological and biochemical composition in sportsmen ergogenic and antioxidant effects of Spirulina supplementation in humans.
  • Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress.
  • Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.
  • Efficacy of Spirulina supplementation on isometric strength and isometric endurance of quadriceps in trained and untrained individuals – a comparative study.
  • Effect of Spirulina maxima on postprandial lipemia in young runners: A preliminary report.
  • Effects of polysaccharide and phycocyanin from Spirulina on peripheral blood and hematopoietic system of bone marrow in mice.
  • Spirulina enhanced the skeletal muscle protein in growing rats.
  • The effect of hydrolyzed Spirulina by malted barley on forced swimming test in ICR mice.

Anaemia

  • The effects of Spirulina on anaemia and immune function in senior citizens.
  • Management of anemia of inflammation in the elderly.
  • Incidence of anaemia and the effect of nutritional supplementation on women in rural and tribal populations of eastern and northeastern India.
  • Effect of Spirulina maxima supplementation on Calcium, Magnesium, Iron, and Zinc status in obese patients with treated hypertension. Iron availability from iron-fortified spirulina by an in vitro digestion/Caco-2 cell culture model.
  • Spirulina platensis feeding inhibited the anaemia- and leucopenia-induced lead and cadmium in rats.
  • Supplementary effect of Spirulina on hematological status of rats during pregnancy and lactation.
  • Update on the pharmacology of Spirulina (Arthrospira), an unconventional food.
  • C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis.
  • Supplementary effect of Spirulina on hematological status of rats during pregnancy and lactation.
  • Spirulina platensis feeding inhibited the anaemia- and leucopenia-induced lead and cadmium in rats.

Cholesterol Control

  • A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
  • Spirulina and its hypolipidemic and antioxidant effects in humans: A systematic review.
  • Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of the Mexican population: A preliminary report.
  • The hepatoprotective and hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population with non-alcoholic fatty liver disease: A prospective pilot study.
  • Hypolipidemic, antioxidant, and anti-inflammatory activities of microalgae Spirulina.
  • Effect of Spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients.
  • Effects of Spirulina platensis supplementation on lipid profile in HIV-infected antiretroviral naïve patients in Yaounde-Cameroon: A randomized trial study.
  • Spirulina Versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats.
  • Effects of long-term supplementation of blue-green algae on lipid metabolism in C57BL/6J mice.
  • Hypolipidemic effect of a blue-green algae (Nostoc commune) is attributed to its non-lipid fraction by decreasing intestinal cholesterol absorption in C57BL/6J Mice.
  • Effects of fish oil and Spirulina on oxidative stress and inflammation in hypercholesterolemic hamsters.
  • Glucomannan and glucomannan plus Spirulina added to pork significantly block dietary cholesterol effects on lipoproteinemia, arylesterase activity, and CYP7A1 expression in Zucker fa/fa rats.
  • A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients.

Blood Pressure

  • Effects of Spirulina consumption on body weight, blood pressure, and endothelial function in overweight hypertensive Caucasians: A double-blind, placebo-controlled, randomized trial.
  • Effects of dietary Spirulina on vascular reactivity.
  • The hepatoprotective and hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population with non-alcoholic fatty liver disease: a prospective pilot study.
  • Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of the Mexican population: A preliminary report.
  • Long-term regulation of the local Renin-Angiotensin System in the myocardium of spontaneously hypertensive rats by feeding bioactive peptides derived from Spirulina platensis.
  • Practical prevention of cardiac remodelling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies.
  • The hypolipidaemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: A prospective study.
  • Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome.
  • A one-week antihypertensive effect of Ile-Gln-Pro in spontaneously hypertensive rats.
  • Effect of food diet supplements with chromium on the clinical and metabolic parameters in type 2 diabetic patients.

Anti-allergy

  • Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients.
  • The role of peptides derived from Spirulina maxima in down-regulation of FcεRI-mediated allergic responses.
  • The effects of Spirulina on allergic rhinitis.
  • Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients.
  • Complementary ENT’: A systematic review of commonly used supplements.
  • Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Spirulina.
  • Clinical potential of phycocyanobilin for induction of T regulatory cells in the management of inflammatory disorders.
  • Complementary and alternative medicine for allergic rhinitis.
  • Class-specific influence of dietary Spirulina platensis on antibody production in mice.
  • Recent patents of complementary and alternative medicine for allergic Rhinitis.
  • Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis.

Diabetes & Blood Sugar Regulation

  • Antidiabetic property of Spirulina.
  • Ameliorative potential of an aqueous cell extract of Spirulina platensis on diabetes-associated metabolic alterations.
  • Role of Spirulina in the control of Glycemia and Lipidemia in Type 2 Diabetes Mellitus.
  • Effect of food diet supplements with chromium on the clinical and metabolic parameters in type 2 diabetic patients.
  • A randomized study to establish the effects of Spirulina in type 2 diabetes mellitus patients.
  • Effect of a zinc-enriched diet on the clinical and metabolic parameters in type 2 diabetic patients.
  • Spirulina Versicolor improves insulin sensitivity and attenuates hyperglycemia-mediated oxidative stress in fructose-fed rats.
  • Studies on the long-term effect of Spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients.
  • A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
  • Glucomannan and glucomannan plus spirulina-enriched squid-surimi added to high saturated diet affect glycemia, plasma and adipose leptin and adiponectin levels in growing fa/fa rats.
  • Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes.
  • Protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan-induced diabetic rats.
  • Exercise and Spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar rats.
  • Study on hypoglycaemic effect of Spirulina platensis on Long-Evans Rats.
  • Attenuation of diabetic complications by C-phycoerythrin in rats: antioxidant activity of C-phycoerythrin including copper-induced lipoprotein and serum oxidation.

Neuroprotective Action

  • Neuroprotective effect of Spirulina fusiform and amantadine in the 6-OHDA induced Parkinsonism in rats.
  • A Spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson‘s disease.
  • Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson‘s disease model in C57BL/6J mice.
  • Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer‘s disease therapy.
  • Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells.
  • Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice.
  • Spirulina non-protein components induce BDNF gene transcription via HO-1 activity in C6 glioma cells.
  • In vitro antioxidant and antiproliferative activities of selenium-containing phycocyanin from selenium-enriched Spirulina platensis.
  • Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats.
  • Hypolipidemic, antioxidant, and anti-inflammatory activities of microalgae Spirulina.

Level 1,140, Fremantle Road Gosnells, WA, 6990 Australia | Tel: +61 (0)41 631 7868